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Solal – SAMe (S-Adenosyl-Methionine) 30 Tabs


SAMe is an amino acid that enhances brain function, improves mood and balances the neurotransmitters serotonin, dopamine and norepinephrine.

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SAMe is an amino acid that enhances brain function, improves mood and balances the neurotransmitters serotonin, dopamine and norepinephrine. It also has powerful liver detoxifying and natural anti-inflammatory effects.

Product Composition

Each tablet contains the following active ingredient:

S-adenosyl-methionine (s-adenosyl-l-methionine disulfate p-toluensulfonate). 400mg

Inactive ingredients: Carboximethylstarch sodium salt, colloidal silica anhydrous, magnesium stearate, mannitol, methacrylic acid copolymer, microcrystalline cellulose, stearic acid, triethyl citrate titanium dioxide. Sugar-free. Suitable for vegans and vegetarians.

Suitable for vegans and vegetarians.

Pharmacological Action

SAMe (s-adenosyl-methionine) is a naturally occurring molecule that occurs in virtually all tissues and fluids. SAMe functions primarily as a methyl donor. A wide variety of molecules accept SAMe’s methyl groups; naturally occurring recipients include proteins, phospholipids, DNA, RNA, hormones, and the energy transporting amino acid creatine. Methylation is essential to the development of the phospholipid bilayer that makes up the outer membranes of normal cells and thereby contributes to membrane fluidity.

SAMe-mediation is also critical for the formation of neurotransmitters in the central nervous system. Hepatic transmethylation is also important as 85% of total body transmethylation occurs in the liver. After donating its methyl group, SAMe is converted to s-adenosylhomocysteine, which initiates the important transsulfuration pathway in the liver, resulting in the generation of glutathione, the most potent antioxidant in the liver. Both folate and vitamin B12 are essential co-nutrients in the metabolism and replenishment of SAMe.

SAMe may be beneficial in joint regeneration due to analgesic and anti-inflammatory effects. Preliminary evidence suggests SAMe might stimulate articular cartilage growth and repair, specifically chondrocyte proteoglycan synthesis and proliferation rate. SAMe might also protect against cytokine-induced cell damage.

Dosage Directions

Take 1 tablet once or twice daily.

Children 7-12 years of age:
Take 1 tablet daily.

Take on an empty stomach at least 30 minutes before a meal. These doses can be doubled if adequate benefit is not obtained after two months of use.

Product Warnings

Do not use this product if you are hypersensitive (allergic) to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Do not exceed recommended dosages unless on the advice of a healthcare practitioner. This medicine has not been evaluated by the Medicines Control Council. This medicine is not intended to diagnose, treat, cure or prevent any disease.

Do not use continually for more than three months without consulting your healthcare practitioner.

Special Precautions:
Do not use SAMe with prescription antidepressants such as Monoamine Oxidase Inhibitors (MAOI’s) or Levodopa or if diagnosed with mania or bipolar disorder, unless under the supervision of a medical practitioner. SAMe can aggravate manic episodes in manic or bipolar individuals.
Surgery: Discontinue SAMe at least two weeks before elective surgery.

Side Effects

Less frequent side effects include insomnia, headaches, nervousness, gastrointestinal complaints, nausea, dizziness or sweating.


SAMe should not be used in manic and bipolar patients as manic episodes could be aggravated.


Monoamine Oxidase Inhibitors (MAOI’s): Because SAMe works in a similar way on serotonin and other neurotransmitters, concurrent use may have additive effects such as hypertension, hyperthermia, agitation, confusion, coma, etc. SAMe should be avoided in individuals taking MAOIs and for two weeks after discontinuing an MAOI.
Antidepressant medicines: Concurrent use might cause additive serotonergic effects and serotonin-like side effects.
Levodopa: SAMe methylates levodopa, which might worsen Parkinson’s symptoms.
The use of SAMe with the following medicines may lead to increased serotonergic effects and should thus be used with caution: Meperidine, dextromethorphan, pentazocine and tramadol.

Pregnancy and Breastfeeding

Safety during pregnancy and whilst breastfeeding has not been established.


The contents of the Knysna Health website shall not be regarded as medical advice, or a basis from which to make medical decisions. The use of information found on this site is completely your responsibility and at your own risk. Our recommendation is that if you have health concerns that you feel unsure about how to deal with, that you contact your trusted health professional for personalized advice.