An amino acid that enhances brain function, improves mood and balances neurotransmitters. It has powerful liver detoxifying and natural anti-inflammatory effects. There are two forms of SAMe: the less effective and less absorbable tosylate form, and the superior butanedisulfonate form.
Each tablet contains the following as active ingredient:
(tablet is enteric coated to protect against stomach acid)
Inactive ingredients: Hydroxypropyl cellulose, sodium hydroxymethyl starch, silica gel, and magnesium stearate.
Although SAMe can be stored at room temperature, below 25°C, it is ideal to store SAMe in the fridge, keep out of the reach of children.
SAMe (s-adenosyl-methionine) is available in various salts with the butanedisulfonate form being the most stable. SAMe is a naturally occurring molecule that occurs in virtually all tissues and fluids. SAMe functions primarily as a methyl donor. A wide variety of molecules accept SAMe’s methyl groups; naturally occurring recipients include proteins, phospholipids, DNA, RNA, hormones, and the energy transporting amino acid creatine. Methylation is essential to the development of the phospholipid bilayer that makes up the outer membranes of normal cells and thereby contributes to membrane fluidity. SAMe-mediation is also critical for the formation of neurotransmitters in the central nervous system. Hepatic transmethylation is also important: 85% of total body transmethylation occurs in the liver. After donating its methyl group, SAMe is converted to s-adenosylhomocysteine, which initiates the important transsulfuration pathway in the liver, resulting in the generation of glutathione, the most potent antioxidant in the liver. Both folate and vitamin B12 are essential co-nutrients in the metabolism and replenishment of SAMe. SAMe may be beneficial in joint regeneration due to analgesic and anti-inflammatory effects. Preliminary evidence suggests SAMe might stimulate articular cartilage growth and repair, specifically chondrocyte proteoglycan synthesis and proliferation rate. SAMe might also protect against cytokine induced cell damage.
Adults and children over 12 years of age: Take 1 tablet once or twice daily. Take on an empty stomach (at least 30 minutes before a meal). Children 7-12 years of age: Take 1 tablet daily. These doses can be doubled if adequate benefit is not obtained after 2 months of use.
Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Safety in children has not been established.
Side effects are rare but, at high doses, can include insomnia, headaches, nervousness, gastrointestinal complaints, nausea, dizziness or sweating.
SAMe should not be used in manic and bipolar patients as manic episodes could be aggravated.
Monoamine Oxidase Inhibitors (MAOI’s): Because SAMe works in a similar way on serotonin and other neurotransmitters, concurrent use may have additive effects such as hypertension, hyperthermia, agitation, confusion, coma, etc. SAMe should be avoided in individuals taking MAOIs and for 2 weeks after discontinuing an MAOI. Antidepressant medicines: Concurrent use might cause additive serotonergic effects and serotonin-like side effects.
Levodopa: SAMe methylates levodopa, which might worsen Parkinson’s symptoms.
The use of SAMe with the following medicines may lead to increased serotonergic effects and should thus be used with caution: Meperidine, dextromethorphan, pentazocine and tramadol.
Do not use SAMe with prescription antidepressants or if diagnosed with mania or bipolar disorder, unless under the supervision of a medical practitioner. SAMe can aggravate manic episodes in manic or bipolar individuals.
Surgery: Discontinue SAMe at least 2 weeks before elective surgery.
Pregnancy & Breastfeeding
Safety in pregnancy and breastfeeding has not been established, do not use.
The contents of the Knysna Health website shall not be regarded as medical advice, or a basis from which to make medical decisions. The use of information found on this site is completely your responsibility and at your own risk. Our recommendation is that if you have health concerns that you feel unsure about how to deal with, that you contact your trusted health professional for personalized advice.