NOW – Methyl Folate 5000 mg 50 Caps

Description

NOW – Methyl Folate 5000 mgn 50 Caps

Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA. Unlike regular folic acid, methylfolate has been shown to penetrate the blood‑brain barrier, where it helps to support neurological health. Quatrefolic® is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.

Supplement Facts & Ingredients:

Supplement Facts (per capsule):

• Folate as (6S)-5-MTHF: 5,000 mcg (which is equivalent to ~8,333 mcg Dietary Folate Equivalent, DFE) in some listings.

Other Ingredients:

• Microcrystalline cellulose

• Hypromellose (vegetable capsule)

• Stearic acid (vegetable source)

• No wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients listed.

✅ Potential Benefits:

1. Improved folate bioavailability

   • The active form of folate (e.g., “methyl‑folate” or 5‑MTHF) is already converted and ready to use by the body, unlike regular folic acid which must undergo several conversion steps.

   • This can be particularly helpful for people with genetic variants (e.g., in the MTHFR gene) which reduce the efficiency of folic acid conversion.

2. Support for methylation, DNA synthesis/repair, and cell division

   • Methylfolate contributes methyl groups in the body’s methylation cycle, which is required for DNA and RNA synthesis, gene expression regulation, and cell division.

   • By supporting these processes, adequate folate status helps with red blood cell maturation (preventing megaloblastic anaemia), and other rapid cell‑turnover states.

3. Homocysteine regulation & cardiovascular support

   • Elevated homocysteine levels are linked to cardiovascular risk and other adverse outcomes. Methylfolate helps convert homocysteine to methionine, thereby lowering homocysteine.

   • This suggests potential cardiovascular benefit in individuals with elevated homocysteine or poor folate metabolism.

4. Support for neurological health / mood / cognitive function

   • Methylfolate is directly involved in the synthesis of key neurotransmitters such as serotonin, dopamine and norepinephrine.

   • Some clinical reviews suggest that in people with depression (especially treatment‑resistant depression) or folate‑metabolism issues, L‑methylfolate can be an adjunct therapy.

   • There is emerging evidence (though not conclusive) for a role in cognitive support, especially in populations with folate deficiency or other risk factors.

5. Pre‑conception and pregnancy support

   • Folate is well‑known for its role in early fetal development (neural tube formation). Having the active form may ensure that folate requirements are met even in people who have conversion difficulties or absorption issues.

Suggested Use:
Take 1 capsule daily with a meal.

Warnings / Cautions:

• For adults only.

• Elderly or individuals with conditions that impair vitamin B12 absorption should frequently check vitamin B12 status when taking high‑dose folate (high folate may mask B12 deficiency).

• If pregnant/nursing or taking medications (especially phenobarbital, phenytoin, primidone, methotrexate) or if you have a medical condition (especially nutrient malabsorption) consult your physician.

Supplement Facts Highlights:

• Serving Size: 1 veg capsule

• Folate: 5,000 mcg (as (6S)-5‑MTHF from Quatrefolic®) which corresponds to ~8,500 mcg DFE (Dietary Folate Equivalent).

• Other ingredients: microcrystalline cellulose, hypromellose (vegetable capsule), stearic acid (vegetable source)

• Allergen information: Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

The contents of the Knysna Health website shall not be regarded as medical advice, or a basis from which to make medical decisions. The use of information found on this site is completely your responsibility and at your own risk. Our recommendation is that if you have health concerns that you feel unsure about how to deal with, that you contact your trusted health professional for personalized advice.